Titlebook: Cytochrome P450; In Vitro Methods and Zhengyin Yan,Gary W. Caldwell Book 2021 The Editor(s) (if applicable) and The Author(s), under exclus

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Assessment of Cytochrome P450 Metabolic Clearance Using Hepatocyte Suspension,tochrome P450 (CYP)-mediated metabolism. Therefore, hepatic clearance is undeniably one of the most critical pharmacokinetic parameters. In the early stages of drug discovery, the in vitro hepatic metabolic stability assay carries great importance as it provides a time- and cost-effective route for

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Cytochrome P450 Knock-Out Assay with Nonselective Inhibitors,an also play a similar role in the metabolism of drugs and other xenobiotics. Oftentimes, CYPs and non-CYP enzymes can share substrate specificity and collectively catalyze oxidative metabolic reactions of the same drug. Therefore, it is of importance in drug discovery to differentiate CYP-mediated

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Differentiation of Cytochrome P450-Mediated from Non-CYP-Mediated Metabolism: Aldehyde Oxidase and as medicinal chemistry strategies evolve to reduce cytochrome P450 (CYP) related drug metabolism. Consequently, there is a need for a differentiation strategy for test compounds to be characterized from those of CYP and molybdenum-containing hydroxylases. Herein, general procedures to identify acti

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In Vitro Reaction Phenotyping of Cytochrome P450 Enzymes,ity in order to assess clinical drug–drug interaction potential and estimate its relative contribution to the overall metabolic clearance in human. CYP phenotyping is commonly carried out using recombinant CYPs, and/or human liver microsomes (HLM) in combination with isoform-specific chemical inhibi

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