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Titlebook: Cyclin Dependent Kinase (CDK) Inhibitors; Peter K. Vogt,Steven I. Reed Book 1998 The Editor(s) (if applicable) and The Author(s), under ex

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发表于 2025-3-21 16:40:59 | 显示全部楼层 |阅读模式
书目名称Cyclin Dependent Kinase (CDK) Inhibitors
编辑Peter K. Vogt,Steven I. Reed
视频video
概述The book is dedicated to the newly characterized class of proteins known as cyclin-dependent kinase inhibitors..It is the first comprehensive collection of review articles on this topic..The book will
丛书名称Current Topics in Microbiology and Immunology
图书封面Titlebook: Cyclin Dependent Kinase (CDK) Inhibitors;  Peter K. Vogt,Steven I. Reed Book 1998 The Editor(s) (if applicable) and The Author(s), under ex
描述More than 10 years ago, the discovery of cyclin-dependent ki­ nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg­ ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led to a simple model for cell cycle control. Modulation of cyclin accumulation, and thereby Cdk activation, was proposed to be the overarching principle governing the passage through cell cycle phases. An­ other reality to emerge from the discovery of Cdks was the ex­ ceptional degree of evolutionary conservation maintained in the machinery and organization of proliferation control. Not only were Cdks shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle
出版日期Book 1998
关键词CDK; CKI; Zellzyklus; biochemistry; biology; cancer; cell; cell cycle; cellular differentiation; cellular gro
版次1
doihttps://doi.org/10.1007/978-3-642-71941-7
isbn_softcover978-3-642-71943-1
isbn_ebook978-3-642-71941-7Series ISSN 0070-217X Series E-ISSN 2196-9965
issn_series 0070-217X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
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发表于 2025-3-21 21:18:22 | 显示全部楼层
Cyclin-Dependent Kinase Inhibitors of , and , ,d other cell cycle components. This article summarizes the current state of the literature on four CKI — Pho85, Sicl, Farl, and Rum1 (Table 1) — with a particular emphasis on placing their activities in the perspective of larger cellular processes.
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Percutaneous Access to the Urinary Tract. 1995; . and . 1996), or by the dominant activation of positive-acting components of the cell cycle machinery, such as the cyclins and cyclin-dependent kinases (CDK) or proto-oncogenes (. 1995a, b; . 1995; . and . 1995).
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0070-217X e collection of review articles on this topic..The book willMore than 10 years ago, the discovery of cyclin-dependent ki­ nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 t
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Samuel C. Kim MD,James E. Lingeman MD, FACSof a mouse gene is now widely used to “knock out” any gene of interest to obtain knowledge of its function. This review focuses on the approaches using knockout mice to understand the physiological function of the cyclin-dependent kinase (CDK) inhibitors.
发表于 2025-3-23 00:59:04 | 显示全部楼层
The INK4 Family of CDK Inhibitors, interfere with differentiation, causing a cell to fail to achieve its fully determined state. Potentially more severe consequences could also ensue from uncontrolled cell division. When this is accompanied by a failure of programmed cell death, a cancerous tumor can result.
发表于 2025-3-23 02:51:14 | 显示全部楼层
Roles of Cyclin-Dependent Kinase Inhibitors: Lessons from Knockout Mice,of a mouse gene is now widely used to “knock out” any gene of interest to obtain knowledge of its function. This review focuses on the approaches using knockout mice to understand the physiological function of the cyclin-dependent kinase (CDK) inhibitors.
发表于 2025-3-23 08:25:28 | 显示全部楼层
Wave Harmonics and Guided Wavesd other cell cycle components. This article summarizes the current state of the literature on four CKI — Pho85, Sicl, Farl, and Rum1 (Table 1) — with a particular emphasis on placing their activities in the perspective of larger cellular processes.
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