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Titlebook: Cyclic AMP, Cell Growth, and the Immune Response; Proceedings of the S Werner Braun,Lawrence M. Lichtenstein,Charles W. P Conference procee

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https://doi.org/10.1007/978-4-431-68228-8mast cells. The same drugs also inhibited lysis of allogeneic target cells (Henney et al., 1972) by sensitized lymphocytes, and they inhibited release of antibody from the splenic lymphocytes of mice immunized with sheep erythrocytes (Melmon et al., 1973a).
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https://doi.org/10.1007/978-981-16-8418-0n part to the difficulty of methodology available for studying the endogenous nucleotide and in part to the inherently tedious task of finding an unknown function of a substance that is present in very small amounts.
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https://doi.org/10.1007/978-4-431-54108-0t PHA causes an early rise in intralymphocytic cyclic AMP concentrations—within 60 sec. (10–12). In longer-incubation experiments, cyclic AMP levels in PHA-stimulated cells eventually fell to below the level in control cells (at 6 and 24 hr), indicating variations in cyclic AMP metabolism in different parts of the cell cycle.
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Aviation, Aerospace, and Transportationking the poly A:U effect to activation of cyclic AMP in spleen cells (Ishizuka et al., 1971). In our laboratory, we have postponed measurements of cyclic AMP, electing first to define the precise cell type affected by this adjuvant.
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Advanced Clinical MRI of the Kidney the hemolytic plaque model of the humoral immune response (Jerne, 1963), as in the models of immediate and delayed hypersensitivity, the effect of these hormones is inhibitory. Furthermore, each of the hormones appears to inhibit plaque formation by stimulating the accumulation of cyclic AMP in lymphocytes.
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The in Vivo Effect of Dibutyryl Cyclic AMP and Immunosuppressive Drugs on the Secondary Antibody Prc immunosuppressive agents have a suppressive effect on the anamnestic IgG and reagin antibody responses, whereas dibutyryl cAMP and theophylline suppress the production of homocytotrophic antibody without effect on IgG production.
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