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Titlebook: Cutaneous Melanoma and Precursor Lesions; Dirk J. Ruiter,Kees Welvaart,Soldano Ferrone Book 1984 Martinus Nijhoff Publishers, Dordrecht 19

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https://doi.org/10.1007/3-7908-1763-5the under side of the tumor have been reported to be of importance in this respect. Olsen (21), Bodenham (3), Davis (9), Milton (20), Shaw et al. (24) and Balch et al. (2) reported that the location of the primary tumor and the patient’s sex are also factors influencing survival.
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https://doi.org/10.1007/3-7908-1763-5mited number of circumstances, like melanomas less than 1 mm thickness or arising in the midline of the head and neck and trunck (9). In all other cases elective node dissection is recommended by many surgeons (1,7,8,9,13).
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Cellular and Molecular Parameters of Tumor Progression in Human Malignant Melanomad may move to stages of higher, respectively lower malignancy depending on exogeneous and endogeneous signals (3-5). The highly malignant cells differ from the premalignant precursors in the expression of different biochemical biological proper-ties, which also include the cell surface (6,7).
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Prognostic Factors for Cutaneous MelanomaThis ability facilitates 1) patient counselling; 2) matching extent of surgery to the severity of the tumor; 3) construction of groups of comparable risk for the evaluation of therapeutic (adjuvant) trials; 4) and understanding of the biologic behavior of the tumor.
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