Titlebook: Cutaneous Drug Eruptions; Diagnosis, Histopath John C. Hall,Brian J. Hall Book 2015 Springer-Verlag London 2015 Allergy.Dermatology Drugs.D

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Fixed Drug Eruptionspresent with a vacuolar dermatitis occurring at the dermo-epidermal junction. Lymphocyte infiltration and hydropic degeneration of keratinocytes develop over the first 24 h following exposure, which can progress to separation of the dermis and epidermis with subepidermal bullae formation. The immuno

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Principles of Diagnosis of Cutaneous Drug Eruptionsonsteroidal anti-inflammatories, sulfa derivatives, antibiotics, anti-seizure medications, and allopurinol. Finding the culprit drug and stopping it can avoid risk of a more systemic reaction such as other organ system damage, anaphylaxis, vasculitis, more severe skin disease, and the known painful

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Histopathology of Drug Reactionso the dermatopathologist if a drug-related condition is suspected. When complicated histologic patterns are in view, the dermatopathologist should have a higher index of suspicion for a drug reaction as well. In this chapter, we will review common drug reactions patterns, and attempt to elucidate he

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Principles of Treatment of Cutaneous Drug Eruptionslized patients. Most reactions are mild and self-limited upon discontinuation of the medication, but severe and life-threatening reactions are also possible. Appropriate management of patients requires a thorough knowledge of the spectrum of drug reactions, the culpability of suspected medications b

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Morbilliform Drug Eruptionsmacules or papules that coalesce to form large plaques. The eruption usually occurs 5 days to 2 weeks after administration of the causative agent. The most common causes are antibiotics, anti-epileptics, allopurinol, non-steroidal anti-inflammatories (NSAIDS), anxiolytics, anti-hypertensives, and di

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Drug-Induced Urticarias. Due to the wide variety of manifestations and etiologies, it is of great importance to rapidly recognize the condition, work up potential causes, and institute appropriate clinical treatment. In this chapter we aim to educate clinicians about the etiology, presentation, and management of the thre

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Erythema Multiforme and Drug Reactionsons. The disease is often self-limited, and treatment is frequently unnecessary. Although many factors have been associated with EM, the study of EM remains difficult due to various inconsistencies in terminology. Herpes simplex virus (HSV) causes the vast majority of EM cases, but drugs and . are a

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