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Titlebook: Cushing’s Syndrome; Lewis S. Blevins (Associate Professor of Medicine Book 2002 Springer Science+Business Media New York 2002 ACTH.hormon

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,Clinical Manifestations and Presentation of Cushing’s Syndrome,gardless of aetiology, is a constellation of clinical and biochemical abnormalities resulting from chronic excess of cortisol. While there are classical features of Cushing’s syndrome, the diagnosis is increasingly being made earlier, before major complications have occurred. An early diagnosis is o
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,Psychiatric Manifestations of Cushing’s Syndrome,lts from chronic exposure to excessive concentrations of glucocorticoids. The physical features of Cushing’s syndrome include weight gain, central obesity (., accumulation of adipose tissue in the facial, nuchal, truncal and girdle areas), facial plethora, hirsutism, cutaneous striae, muscle wasting
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,A Rational Approach to the Patient Suspected of Having Cushing’s Syndrome,, mania and death.” In particular, Osler was impressed by the rapid weight gain and the “bloated” appearance of his patient’s face. Unfortunately, however, the constellation of symptoms and signs that we now attribute to glucocorticoid excess had not been described and the patient succumbed while be
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,Evaluation of Cushing’s Syndrome,tures are present diagnosis may be straightforward. In contrast, when physical symptoms and signs are subtle diagnosis may be far more taxing. The principal biochemical features of Cushing’s syndrome are an excess endogenous integrated secretion of cortisol, loss of the normal feed-back of the hypot
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Syndrome of Ectopic ACTH Hypersecretion,on numerous occasions in the first half of the twentieth century it was not until 1962 that evidence for direct secretion of adrenocorticotropin (ACTH) from such tumors was documented. Ectopic (that is, nonpituitary) ACTH production accounts for about 10–15% of cases of ACTH-dependent Cushing’s synd
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,Cushing’s Syndrome Due to Adrenal Disorders, of the adrenal glands that secrete cortisol in an autonomous fashion and lead to the development of Cushing’s syndrome are listed in Table 1. Benign and malignant adrenocortical neoplasms account for a majority of the cases. Although rare, the various adrenal hyperplasias represent an interesting s
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