Titlebook: Current and Future Immunosuppressive Therapies Following Transplantation; Mohamed H. Sayegh,Giuseppe Remuzzi Book 2001 Springer Science+Bu

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Clinical Trials in Transplant Immunosuppression: What Have We Learned?sease. Randomization minimizes selection bias and prevents bias in the comparison between study groups due to regression toward the mean. However, there is no guarantee that bias is entirely eliminated even in a prospective study with double blinding.

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Use of Corticosteroids in Kidney Transplantionllograft rejection was first reported in the early 1960s [2],[3]. Thereafter, combination of azathioprine and steroids became the conventional maintenance immunosuppression regimen in organ transplantation and remained so for almost two decades.

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Mycophenolate Mofetil and Azathioprined trials that mycophenolate mofetil (MMF) had better efficacy for the prevention of acute rejection following renal transplantation [3–5]. Although MMF has replaced azathioprine in chronic immunosuppression protocols, many centers still use azathioprine, particularly in low-risk patients.

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Monoclonal Antibody Targeting of the T Cell Receptor Complex81, few years before it could be firmly established that the specific molecular target of OKT3 was one of the polypeptide chains included within the major T cell recognition element namely, the T cell antigen receptor (TCR)/CD3 complex.

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Book 2001 the basic science mechanisms andclinical applicability of these strategies. The uniqueness of thisbook is the inclusion of up-to-date information on the basicmechanisms of actions of the immunosuppressive drugs as well as asummary of the clinical trials data and the potential use of thesedrugs in c

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Clinical Trials in Transplant Immunosuppression: What Have We Learned?e. The experimental design most appropriate for the comparison of therapeutic intervention is the randomized controlled clinical trial. These trials are designed to assess the efficacy of treatment in quantitative terms which are frequency of defined events (primary end-points) and time course of di