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Titlebook: Current Topics in Heart Failure; Experimental and Cli Rainer W. Gülch,Gerolf Kissling Book 1991 Springer-Verlag Berlin Heidelberg 1991 expe

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The role of adrenergic system in regulation of cardiac myosin heavy chain gene expressionas well as nutritional and hormonal states of the animal Several lines of evidence indicate that the adrenergic nervous system plays an important role in the redistribution of myosin isoforms in the heart. For example, chemical sympathectomy favors the expression of V. isomyosin at the expense of V.
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Large and rapid changes of myofibrillar total calcium during the cardiac cycle. Electron probe microontraction to the maximum, the cells were shock-frozen for electron probe microanalysis (EPMA). Shock-freezing was timed at the end of diastole (− 80 mV) or at different times during systole (+ 5 mV)..The same paired-pulse protocol was applied to another group of myocytes from which contraction was
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Are antisarcolemmal (ASAs) and antimyolemmal antibodies (AMLAs) “natural” antibodies?ae. Since they may also occur to a much lesser incidence with increasing age, it was examined whether they also possess properties of “natural antibodies”. As natural antibodies, AMLAs and ASAs have specificity for conserved structures on the membrane. They possess cross-reactivity and increase with
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Role of neuroendocrine mechanisms in the pathogenesis of heart failure diastolic function of the myocardium, and indirectly, by modulation of pre- and afterload. Important vasoconstrictor, fluid- and sodium-retaining factors are the renin-angiotensin-aldosterone system, sympathetic nerve activity, and vasopressin; vasodilator, volume, and sodium-eliminating factors ar
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Modulation of baroreflex and baroreceptor function in experimental heart failure is depressed in both humans and animals with heart failure. The mechanisms for these abnormalities have not been well worked out. We have carried out experiments to determine the relative roles of the various components involved in the arterial baroreflex arc which may be abnormal in chronic heart
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Does converting enzyme inhibition change the neuronal and extraneuronal uptake of catecholamines?served. Therefore, we investigated the effects of the long-acting converting enzyme inhibitor ramipril on the neuronal and extraneuronal uptake of SHR. Ramipril was administered either i.v. or orally to SHR, whereas desipramine or corticosterone were additionally infused to block the neuronal or ext
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