| 书目名称 | Current Concepts in Autoimmunity and Chronic Inflammation |
| 编辑 | Andreas Radbruch,Peter E. Lipsky |
| 视频video | http://file.papertrans.cn/242/241148/241148.mp4 |
| 概述 | Discusses the complex ethiopathologies of autoimmune diseases.Explores the broad variety of cell types and genes involved.Shows how initiating factors in autoimmune disease can possibly be distinct fr |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | The immune system has been known to be capable of distinguishing self from non-self since the pioneering work of Paul Erhlich more than a century ago. Originally described in experiments studying blood transfusion comp- ibility, the principle of “horror autotoxicus” is still valid, although today the phenomenon is usually described in terms of tolerance or ignorance. A great deal has been learned about the various processes preventing self-reactivity normally. These include processes that operate during immune cell ontogeny and subsequently on reactivity of mature lymphocytes in the periphery. They encompass mechanisms that are intrinsic to potentially reactive lymphocytes and can result in central or peripheral deletion or the alteration of functional potential. In addition, there are in?uences that are extrinsic to potentially auto-reactive lymphocytes, including the function of regulatory cells, d- ferentiation state of antigen-presenting cells, availability of self-antigen, the cytokine and chemokine milieu, as well as the traf?cking patterns involved in generating productive immune interactions. It is clear that the immune system devotes a considerable effort to the avoidance |
| 出版日期 | Book 2006 |
| 关键词 | T cell; apoptosis; autoimmune disease; autoimmunity; cell; cytokine; diseases; genes; genetics; infection; mac |
| 版次 | 1 |
| doi | https://doi.org/10.1007/3-540-29714-6 |
| isbn_softcover | 978-3-642-06745-7 |
| isbn_ebook | 978-3-540-29714-7Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
|Archiver|手机版|小黑屋|
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