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Titlebook: Critical Issues in Head and Neck Oncology; Key Concepts from th Jan B. Vermorken,Volker Budach,Brian O‘Sullivan Conference proceedings‘‘‘‘‘

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Immune Checkpoint Inhibitors in the Curative Setting: Pre-clinical and Clinical Data,ts with inoperable recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). For curable HNSCC, the role of immunotherapy is under investigation. In this chapter, we briefly review the current use of immunotherapy with surgery or radio(chemo)therapy in the treatment of HNSCC with curative intent.
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ows surgeons to plan resection and reconstruction to a high degree of precision, with a number of associated benefits. This chapter discusses the indications and processes involved in three-dimensional planning and its application to surgical resection and reconstruction of the facial bones.
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The Bi-Directional Communication Between Tumour Cells and Other Components of the Tumour Microenviruch example stems from the discovery that malignant melanomas with metastatic potential can downregulate autophagy in the overlying epidermis. Autophagy is essential for normal keratinocyte maturation. AMBRA1 is a key autophagy regulatory molecule and its expression in the epidermis is reduced in th
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Immune Checkpoint Inhibition and Radiotherapy in Head and Neck Squamous Cell Carcinoma: Synergisms d/or metastatic stages. Clinical responses are impressive but remain limited to a minority of patients. Primary resistance of never-responders is considered to derive from host- and tumor-specific characteristics, the latter comprising tumor immune checkpoint activity, immune contexture, tumor mutat
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