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Titlebook: Creatine and Creatine Kinase in Health and Disease; Gajja S. Salomons,Markus Wyss Book 2007 Springer Science+Business Media B.V. 2007 bios

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Early Evolution of the Creatine Kinase Gene Family and the Capacity for Creatine Biosynthesis and Mlts support the view that the capacity for creatine biosynthesis and membrane transport may have evolved quite early, perhaps coincident with CK. Conventional wisdom would suggest that CK evolved from an ancestral protein most similar to the CK homologue, arginine kinase. This early CK gene subseque
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Expression and Function of Agat, Gamt and CT1 in the Mammalian Brain,inotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT). Creatine (Cr) is taken up by cells through a specific transporter, CT1. While the major part of endogenous synthesis of Cr is thought to occur in kidney, pancreas and liver, the brain widely expresses ., . and ., both during develo
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A Novel Relationship Between Creatine Transport at the Blood-Brain and Blood-Retinal Barriers, Creae proper development and function. Thus, our understanding of the mechanism of creatine supply and creatine usage in the brain and retina and of creatine supplementation in patients with creatine deficiency syndromes is an important step towards improved therapeutic strategies for brain and retinal
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Pre-Symptomatic Treatment of Creatine Biosynthesis Defects, first evidence for important therapeutic effects of pre-symptomatic treatment with creatine (Cr) supplementation in AGAT-D and Cr supplementation plus guanidinoacetate lowering strategies in GAMT-D. Although long-term data are lacking, the results suggest that complete prevention of neurological se
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