书目名称 | Controlled Clinical Trials in Neurological Disease | 编辑 | Roger J. Porter,Bruce S. Schoenberg | 视频video | | 丛书名称 | Foundations of Neurology | 图书封面 |  | 描述 | The evaluation of the efficacy and safety of a clinical tool, be it a diagnostic technique, a preventive methodology, or a therapeutic intervention, is an im portant responsibility of physicians. The history of medicine is characterized by the authoritarianisms of teachers and of organizations giving way to the clinical experience of physicians; authoritarian dictum was replaced by case report and then by case series. As physicians learned to substitute the analysis of data for the inconsistencies of dictums and anecdotes, the problems of the case series as an investigative tool became more evident: patient selection criteria, measurements of outcome, significance of results, and extrapolation of conclusions to the community of patients. In response to these issues, the methodology of the controlled clinical trial has evolved and with it the instru ments of study design and of biostatistics as aids to study design and data analysis. The medical - surgical armamentarium has evolved from being dependent solely upon the observations and conclusions of a skilled clinician to being constructed upon the systematic collection and evaluation of data by a team of skilled clinicians and th | 出版日期 | Book 1990 | 关键词 | Alzheimer; Nervous System; alzheimer‘s disease; brain; brain tumor; neuroscience; spinal cord; tumor | 版次 | 1 | doi | https://doi.org/10.1007/978-1-4613-1495-0 | isbn_softcover | 978-1-4612-8804-6 | isbn_ebook | 978-1-4613-1495-0Series ISSN 0924-8935 | issn_series | 0924-8935 | copyright | Kluwer Academic Publishers 1990 |
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