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Titlebook: Controlled Clinical Trials in Neurological Disease; Roger J. Porter,Bruce S. Schoenberg Book 1990 Kluwer Academic Publishers 1990 Alzheime

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书目名称Controlled Clinical Trials in Neurological Disease
编辑Roger J. Porter,Bruce S. Schoenberg
视频video
丛书名称Foundations of Neurology
图书封面Titlebook: Controlled Clinical Trials in Neurological Disease;  Roger J. Porter,Bruce S. Schoenberg Book 1990 Kluwer Academic Publishers 1990 Alzheime
描述The evaluation of the efficacy and safety of a clinical tool, be it a diagnostic technique, a preventive methodology, or a therapeutic intervention, is an im­ portant responsibility of physicians. The history of medicine is characterized by the authoritarianisms of teachers and of organizations giving way to the clinical experience of physicians; authoritarian dictum was replaced by case report and then by case series. As physicians learned to substitute the analysis of data for the inconsistencies of dictums and anecdotes, the problems of the case series as an investigative tool became more evident: patient selection criteria, measurements of outcome, significance of results, and extrapolation of conclusions to the community of patients. In response to these issues, the methodology of the controlled clinical trial has evolved and with it the instru­ ments of study design and of biostatistics as aids to study design and data analysis. The medical - surgical armamentarium has evolved from being dependent solely upon the observations and conclusions of a skilled clinician to being constructed upon the systematic collection and evaluation of data by a team of skilled clinicians and th
出版日期Book 1990
关键词Alzheimer; Nervous System; alzheimer‘s disease; brain; brain tumor; neuroscience; spinal cord; tumor
版次1
doihttps://doi.org/10.1007/978-1-4613-1495-0
isbn_softcover978-1-4612-8804-6
isbn_ebook978-1-4613-1495-0Series ISSN 0924-8935
issn_series 0924-8935
copyrightKluwer Academic Publishers 1990
The information of publication is updating

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Perspective of the Participating Investigatorperiod, no new anticonvulsant drug had been entered into therapeutic use in the United States for approximately eight years. Epileptic seizures were not then categorized with great accuracy and, as described by Coats worth [1], there had been few adequate clinical trials even for those drugs in comm
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Perspective of the Clinical Centerotocol. In order to accomplish the objectives of the project and test the defined hypothesis, there are key elements that must exist at the site. These elements are reputation and expertise, an organizational structure to support clinical research, appropriate and dedicated personnel, and adequate f
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Perspective of the Pharmaceutical Industrying to drug discovery are spearheaded primarily by the pharmaceutical industry. The compounds discovered possess physical and pharmacologic properties that are categorized. For many years, the task of anticonvulsant design was approached by modifying the heterocyclic ring structure of existing agent
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