Titlebook: Control of Metabolic Processes; Athel Cornish-Bowden,María Luz Cárdenas Book 1990 Springer Science+Business Media New York 1990 Amino acid

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Properties Needed for the Enzymes of an Interconvertible Cascade to Generate a Highly Sensitive Resp between 10% and 90% of full activity) if its concentration increases at least three-fold. Even a Hill coefficient as high as 6, rarely seen in nature, would only lower this ratio to two-fold. Furthermore, as flux control coefficients in reality are usually less than unity, the sensitivity of the pathway to the effector is decreased accordingly.

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Recent Studies on Borel Directions,ral metabolic system, though the specific example treated in their paper was a linear pathway. Their methods of deriving expressions for flux control coefficients could be applied to other pathways [for example, a branched pathway: Kacser (1983)1, but on a case by case argument from first principles.

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History and Original Thoughts on the Control Theoretic Approachhall nevertheless address this history in those terms. Hopefully some grandchildren will be reading too. But let me note at the outset that I am not a scientific historian and that I present this history from a rather personal view.

Exonerate

Control Coefficients and the Matrix Methodral metabolic system, though the specific example treated in their paper was a linear pathway. Their methods of deriving expressions for flux control coefficients could be applied to other pathways [for example, a branched pathway: Kacser (1983)1, but on a case by case argument from first principles.

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Book 1990It sets out to present the current state of understanding of the principles governing the way fluxes and concentrations are maintained and controlled in metabolic systems. Although this is a topic that has held the interest of biochemists for many years, it is only quite recently that the methods of

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The Nature and Role of Theory in Metabolic Controlscience. In this introductory chapter, therefore, I plan to discuss these questions, with the hope of providing a context in which the claims of metabolic control theory as a legitimate theory can be discussed. Elsewhere (Cornish-Bowden, 1989) I have discussed the criticisms of metabolic control the

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断言

Comparison of Accuracy of Alternative Models for Biochemical Pathwaysageau, 1989.), and of the specific operations involved in the execution of an analysis (as described by Savageau in Chapter 4 of this book) all have shown that these three theories are related variants based on the ., even though some of the specific aims and applications of each approach may appear

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