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Titlebook: Control of Metabolic Processes; Athel Cornish-Bowden,María Luz Cárdenas Book 1990 Springer Science+Business Media New York 1990 Amino acid

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书目名称Control of Metabolic Processes
编辑Athel Cornish-Bowden,María Luz Cárdenas
视频video
丛书名称NATO Science Series A:
图书封面Titlebook: Control of Metabolic Processes;  Athel Cornish-Bowden,María Luz Cárdenas Book 1990 Springer Science+Business Media New York 1990 Amino acid
描述THIS BOOK collects together papers given at a NATO Advanced Research Workshop held at Il Ciocco (Lucca), Italy, from the 9th to the 15th April, 1989. It sets out to present the current state of understanding of the principles governing the way fluxes and concentrations are maintained and controlled in metabolic systems. Although this is a topic that has held the interest of biochemists for many years, it is only quite recently that the methods of analysing the kinetics of multi-enzyme pathways developed over the past two decades have come to be widely discussed or applied experimentally. Many biochemists remain sceptical that the new methods offer a real advance (except in complexity) over the landmark discoveries of the 1950s and 1960s relating to inhibition of enzymes at branch-points by the end products of metabolic pathways, and the interpretation of allosteric effects and cooperativity. Even those who have become convinced that the classical ideas provide only the starting point for understanding metabolic control have been by no means unanimous in their assess­ ment of the direction in which one should advance. In this book we have tried to include all of the current points o
出版日期Book 1990
关键词Amino acid; Glutamin; Glycogen; Nucleotide; Purine; Termination; biosynthesis; enzymes; gene expression; gene
版次1
doihttps://doi.org/10.1007/978-1-4757-9856-2
isbn_softcover978-1-4757-9858-6
isbn_ebook978-1-4757-9856-2
copyrightSpringer Science+Business Media New York 1990
The information of publication is updating

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Peter A. Wieringa,Henk G. Stassenyond the threshold-generating step. Control of flux indeed appears to be distributed over the various steps of a pathway (Kacser & Bums, 1973; Westerhoff ., 1984). The reversible shutting down of the flux above a suprathreshold stimulation should, however, prove a most efficient way of generating sharp transitions under steady-state conditions.
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Essentials of Nevanlinna Theory,s. This does not necessarily imply that control analysis is better than the other two theories. It does, however, suggest that control analysis is easier to understand for the mathematically untrained.
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David D. Woods,Nadine B. Sarter between 10% and 90% of full activity) if its concentration increases at least three-fold. Even a Hill coefficient as high as 6, rarely seen in nature, would only lower this ratio to two-fold. Furthermore, as flux control coefficients in reality are usually less than unity, the sensitivity of the pathway to the effector is decreased accordingly.
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Modern Control Theories: a Consumers’ Tests. This does not necessarily imply that control analysis is better than the other two theories. It does, however, suggest that control analysis is easier to understand for the mathematically untrained.
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