Titlebook: Control of Biofilm Infections by Signal Manipulation; Naomi Balaban Book 2008 Springer-Verlag Berlin Heidelberg 2008 antibiotics.bacteremi

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1863-9607 ts of emphasis. When our race was threatened by epidemic diseases, we visualized bacteria as swarms of potentially lethal planktoniccells from which we must remain isolated by sanita978-3-642-09309-8978-3-540-73853-4Series ISSN 1863-9607 Series E-ISSN 1863-9615

Noisome

Introduction,roaches to the prevention and treatment of biofilm infections. Such alternative approaches are described in subsequent chapters, culminating with clinical studies that describe treating otherwise untreatable wound infections with the aid of antibiofilm approaches.

ALB

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Quorum-Sensing Inhibitory Compounds, antagonists is critical. In this chapter, we introduce a class ofcompounds, brominated furanones, which have a broad spectrum ofactivities against bacterial multicellular behaviors, such as biofilmformation and quorum sensing. The application of these compounds and themechanisms of inhibition are r

Highbrow

BROW

Animal Models Commonly Used to Study Quorum-Sensing Inhibitors, the simple nematode-killing and amoeba-plate-killing assays, to modelswith more relevance to human disease like the pulmonary and cellulitisinfection models in mice, the graft prosthesis, and the central venouscatheter infection models in rats, and the endocarditis and osteomyelitisinfection models

FLIP

In Vivo Studies: Inhibiting Biofilm-Associated Bacterial Infections Using QSIs,l studies include the use of biofilm inhibitors to suppress . lung infections in mice, and the use of biofilm inhibitors to suppress antibiotic-resistant staphylococcal infections like methicillin-resistant . in rat graft and central venous catheter models and mouse cellulitis models. The advantages

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Ironing Out the Biofilm Problem:The Role of Iron in Biofilm Formation,ics. Like most other pathogens,. is under intense competition with the host foriron. Recent studies show that even when there is sufficient iron for growth,this element serves as a signal for biofilm development. Here, we summarizeour knowledge of the role iron plays in . biofilmdevelopment. Novel t