Titlebook: Congenital Bleeding Disorders; Diagnosis and Manage Akbar Dorgalaleh Book 2023Latest edition The Editor(s) (if applicable) and The Author(s

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Combined Factor V and Factor VIII Deficiency, Diagnosis, and Managementa simultaneous decrease of plasma FV and FVIII, usually between 5% and 30%, and is associated with a mild to moderate bleeding tendency. Women have more physiological conditions (menstrual cycle and delivery) for developing pathological bleeding. The bleeding phenotype of F5F8D is relatively similar

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Congenital Factor X Deficiency, Diagnosis, and Managementin the coagulation cascade. After activation, activated FX (FXa) is the first enzyme in the common coagulation pathway and plays a key role in thrombin generation. Congenital FX deficiency is a very rare bleeding disorder that is inherited in an autosomal recessive manner estimated to occur in 1:1,0

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Congenital Factor XI Deficiency, Diagnosis and Managementmillion in the general population, but in specific populations such as Ashkenazi Jews, the prevalence is as high as 1 per 450 individuals. FXI deficiency is a mild bleeding disorder mostly associated with post-traumatic or postsurgical hemorrhages or unexplained minor bleeding. Based on FXI activity

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Glanzmann Thrombasthenia: Diagnosis and Management (GP) IIb/IIIa). The disorder manifests with mucocutaneous bleeding early in life. Although purpura, epistaxis, gum bleeding, and menorrhagia are the most common clinical presentations, life-threatening hemorrhage can occur with fatal consequences. GT has a distinct laboratory feature with the absen

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