Titlebook: Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models; Aslak Tveito,Glenn T. Lines Book‘‘‘‘‘‘‘‘ 2016 The

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Two-Dimensional Calcium Release,The essence of calcium-induced calcium release is once more illustrated in Fig. 5.1. This figure is very similar to Fig. 2.1 on page 24 except that the box surrounded by a thin red line is now slightly extended.

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Computing Theoretical Drugs in the Two-Dimensional Case,Let us briefly recall the difficulty we want to overcome with the theoretical drug. The difficulty is that in the prototypical reaction defined by the Markov model. the rates may change under various mutations. One case that we have focused on in these notes is CO-mutations where the reaction rate from C to O is increased.