Titlebook: Computational Systems Neurobiology; N. Le Novère Book 2012 Springer Science+Business Media Dordrecht 2012 computational neurobiology.dynam

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Book 2012s book introduces the many different types of computational studies one can develop to study neuronal systems. It is aimed at undergraduate students starting their research in computational neurobiology or more senior researchers who would like, or need, to move towards computational approaches. Bas

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Functional Genomics and Molecular Networks Gene Expression Regulations in Complex Diseases: Down Syroughput technologies such as microarrays and data analysis. The power of this approach allowed to study complex biological functions as well as diseases. In this chapter, we introduce functional genomics and describe the statistical methods that are used to find differentially expressed genes. We a

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Reconstructing Models from Proteomics Data, fraction preparation, protein complex isolation and mass spectrometry identification methods has led to a great accumulation of synaptic proteomics data. In order to gain a better insight of how the synaptic proteome is organised in molecular complexes identified from the biochemical analysis of ne

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Breakdown of Mass-Action Laws in Biochemical Computation,articularly neurons and other types of cells. This type of phenomena typically takes place at the nano- to micro-scale levels. An increasing number of studies show that the classical diffusion process dominated by Brownian motion cannot be directly applied to cells. Instead, a process called anomalo

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The Performance (and Limits) of Simple Neuron Models: Generalizations of the Leaky Integrate-and-Fithe activity of single neurons can be done by mathematical models of various complexity. In this chapter we start with the integrate-and-fire model, and then consider a set of enhancements so as to approach the behaviour of multiple types of real neurons.

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Noise in Neurons and Other Constraints,e action potential, the fundamental electrical signal of the brain, because malfunction of the action potential causes many neurological conditions. The action potential is mediated by the concerted action of voltagegated ion channels and relating the properties of these signalling molecules to the