Titlebook: Computational Modeling in Tissue Engineering; Liesbet Geris Book 2013 Springer-Verlag Berlin Heidelberg 2013 Biological Response.Biologica

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Image-Based Cell Quality Assessment: Modeling of Cell Morphology and Quality for Clinical Cell Ther are facing limitations in the quality assurance step of cell production for clinical therapy. Image-based cell quality assessment offers a great potential, because it is the only way to non-destructively and repeatedly assess cellular phenotypes and irregularities. To effectively assess cell qualit

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Continuum Modelling of In Vitro Tissue Engineering: A Review,ed organ transplant, which is increasingly hampered by a shortage of available tissue. The complexity of the myriad biophysical and biochemical processes that together regulate tissue growth renders almost impossible understanding by experimental investigation alone. Mathematical modelling applied t

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Multiphysics Computational Modeling in Cartilage Tissue Engineering,ns or under medium perfusion in a bioreactor. An essential step toward the development of functional cartilage is to understand and control the tissue growth phenomenon in such systems. The growth process depends on various space- and time-varying biophysical variables of the environment surrounding

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Oxygen Transport in Bioreactors for Engineered Vascular Tissues, nutrient delivery and metabolite removal. Some bioreactor culture methods employ mechanical stimulation to improve material strength and stiffness; however, even with mechanical stimulation, engineered tissues are likely to operate in a diffusional transport regime for nutrient delivery and metabol

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Multi-Scale Modelling of Vascular Disease: Abdominal Aortic Aneurysm Evolution,titutive model that accounts for the structural arrangement of collagen fibres in the medial and adventitial layers, the natural reference configurations in which the collagen fibres are recruited to load bearing and the (normalised) mass-density of the elastinous and collagenous constituents. Growt

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Computational Mechanobiology in Cartilage and Bone Tissue Engineering: From Cell Phenotype to Tissutissue regeneration on multiple levels, from cell phenotype to tissue architecture. The chapter begins with a brief review of single cell models with a focus on cell-substrate interactions and cytoskeletal remodelling. After summarising a number of current theories for mechanoregulated tissue differ

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Mechanobiological Modelling of Angiogenesis: Impact on Tissue Engineering and Bone Regeneration, depends on the ability of new blood vessels to grow. Capillary growth and its impact on human health has been focus of intense research from an in vivo, in vitro and in silico perspective. In fact, over the last decade many mathematical models have been proposed to understand and simulate the vascu

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Mathematical Modelling of Regeneration of a Tissue-Engineered Trachea,achea (Macchiarini et al. The Lancet 372(9655), 2023–2030). This land-mark operation has paved the way for developing a host of successful stem cell-based therapies for treating disease, and the exciting possibility of the tissue engineering of whole organs. It has also provided the opportunity for

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Book 2013 robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can hel