Titlebook: Computational Methods in Systems Biology; 6th International Co Monika Heiner,Adelinde M. Uhrmacher Conference proceedings 2008 Springer-Ver

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Automatic Complexity Analysis and Model Reduction of Nonlinear Biochemical Systems,t time scales. In this paper we present and apply two novel methods aimed at automatic complexity and model reduction by numerical algorithms. The first method combines dynamic sensitivity analysis with singular value decomposition. The aim is to determine the minimal dimension of the kinetic model

未开化

Formal Analysis of Abnormal Excitation in Cardiac Tissue,mal analysis of cardiac arrhythmic events, namely Early Afterdepolarizations (EADs). The goal is to quantify (for the first time) the contribution of the overall sodium (Na.), potassium (K.) and calcium (Ca.) currents to the occurrence of EADs during the plateau phase of the cardiac action potential

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,SED-ML – An XML Format for the Implementation of the MIASE Guidelines,epted formats to encode the structure of models. However, the problem of describing the simulations to be run using those models has not yet been tackled in a satisfactory way. The community believes that providing detailed information about simulation recipes will highly improve the efficient use o

旧式步枪

On Parallel Stochastic Simulation of Diffusive Systems,lgorithms to simulate them, including the well-known and widespread Gillespie SSA, are strictly sequential. Here we investigate, in a general way, how to characterize the simulation of biochemical systems in terms of Discrete Event Simulation. We dissect their inherent parallelism in order both to e

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Conference proceedings 2008tock, Germany, in September 2008. The 21 revised full papers presented together with the summaries of 5 invited papers were carefully reviewed and selected from more than 60 submissions. The papers cover theoretical or applied contributions that are motivated by a biological question focusing on mod