Titlebook: Computational Methods in Systems Biology; 16th International C Milan Češka,David Šafránek Conference proceedings 2018 Springer Nature Switz

cathartic

扩大

Programs to Improve Physical Health,e . dynamics of RNA production of . promoters at the single event level. This dynamics is mostly controlled at the promoter region, which can be engineered with single nucleotide precision. Based on these developments, we propose a new strategy to engineer genes with predefined transcription dynamic

新陈代谢

https://doi.org/10.1007/978-1-4899-0065-4 to High Performance Computing (HPC) facilities, particularly when each cell is described by a detailed model of some intra-cellular pathways and cells are coupled and interacting at the tissue level. Model abstraction can play a crucial role in this setting, by providing simpler models of intra-cel

CHOIR

https://doi.org/10.1007/978-1-4419-9120-1an organism, based on information present in its genome. Such models have been designed so that flux balance analysis (FBA) can be applied in order to analyse metabolism under steady state. For this purpose, a biomass function is added to these models as an overall indicator of the model’s viability

Interstellar

https://doi.org/10.1007/978-1-4419-9120-1. system has been proposed recently to learn logical models from time series data. It uses Answer Set Programming to enumerate Boolean Networks (BNs) given prior knowledge networks and phosphoproteomic time series data. In the resulting sequence of solutions, similar BNs are typically clustered toge

INCH

https://doi.org/10.1007/978-1-4419-9120-1s nodes that are labeled with the containing chemicals and the transport channels are similarly viewed as labeled edges between the nodes. Understanding VTSs is an ongoing area of research and for many cells they are partially known. For example, there may be undiscovered edges, nodes, or their labe

填满

https://doi.org/10.1007/978-1-4419-9120-1s have been associated with certain dynamical behaviors and define key modules that are important for understanding complex biological programs. Besides studying the properties of motifs in isolation, existing algorithms often evaluate the occurrence frequency of a specific motif in a given biologic

参考书目

Denise Belchetz,Kenneth Leithwoodere we study one such system, which is broadly inspired by the interaction between an mRNA molecule and an antagonistic microRNA molecule encoded by the same gene. The two reaction species are synchronously produced, individually degraded, and the second species (microRNA) exerts an antagonistic pre

GUILE

Custodian

https://doi.org/10.1007/978-3-658-38276-6put machinery, while computational models are synthesized or inferred automatically from data. However, integration between automated tasks in the process of biological discovery is still lacking, largely due to incompatible or missing formal representations. While theories are expressed formally as