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Titlebook: Computational Methods in Systems Biology; 21st International C Jun Pang,Joachim Niehren Conference proceedings 2023 The Editor(s) (if appli

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Overview of the decision-making procedure interactions is not completely known. Phenotype control aims to stabilise the network in states exhibiting specific traits..In this paper, we define the phenotype control problem in the context of asynchronous PSBNs and propose a novel semi-symbolic algorithm for solving this problem with permanent
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Information procurement decisionsems. To that end, we consider the case of a colony of foraging ants, where, for the combined effect of known biological mechanisms such as stigmergic interaction, pheromone release, and path integration, the ants will progressively work out the shortest path to move back and forth between their nest
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Developing and evaluating optionsParticularly, unsupervised deep learning models provide state-of-the-art solutions for the most common tasks that arise when dealing with scRNA-seq data. However, the biological usefulness of these complex models is burdened by their black-box nature. To address such limitations several lines of res
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Information procurement decisionshin a cell, are often regarded as virtually deterministic dynamical systems. However, this view is now being challenged by the fundamentally stochastic, ‘bursty’ nature of gene expression revealed at the single cell level. We present a Python package called Harissa which is dedicated to simulation a
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Overview of decision-making procedure reduction techniques can be used to project the system onto a lower-dimensional state space. Constrained lumping can reduce systems of ordinary differential equations with polynomial derivatives up to linear combinations of the original variables while preserving specific output variables of intere
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