Clinical Applications of Pharmacokinetics and Control Theory: Planning, Monitoring, and Adjusting Dosage Regimens of Aminoglycosides, Lidocaine, Digitoxin, and Digoxin,creased to 100 mg every 8 hr. However, his serum creatinine rose to 1.5, and the aminoglycoside levels became much higher, as shown. When these results became known, his dose was reduced to 80 mg once again. However, his serum creatinine had now risen to 2.0 and 2.1 on two separate measurements, and his “trough” gentamicin level was 4.1 µtg/ml. |