Titlebook: Combination Therapies; Biological Response Allan L. Goldstein,Enrico Garaci Book 1992 Plenum Publishing Corporation 1992 AIDS.gene therapy

Heresy

The Role of Combination Biologic Therapy in the Immunotherapeutic Approach to the Treatment of Renalh advanced local or distant disease. Approximately two-thirds of the all locally confined renal tumors are found incidentally (1). Surgical extirpation is the cornerstone of therapy of localized RCC. In spite of years of research and many clinical trials, the management of metastatic disease remains undefined.

细胞膜

Combination Therapies with Cytokines and Anti-Cytokines in Murine Opportunistic Infectionsnding of the mechanisms of resistance, and have also provided new clues to the elucidation of the mechanisms of both resistance and pathology, such that the use of cytokines or anti-cytokines appears to be extremely promising for treatment of conditions associated with microbial infection.

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Use of IL-2 and Lymphocytes Following Bone Marrow Transplantationration of IL-2 with or without reinfusion of .-generated LAK cells [2] represents one possible consolidative treatment modality which, if used after BMT, might exert an anti-tumor effect against the minimal residual disease which is assumed to persist after BMT, and thereby prevent or delay recurrence of the malignancy.

欢呼

Combination of Fluorouracil and Interferon: Mechanisms of Interaction and Clinical Studiesr developing combination chemotherapy regimens, such as increasing dose intensity and combining drugs that have independent antitumor activity, may not apply to those for combining BRMs and cytotoxic drugs. Thus, the rationale for adding BRMs to chemotherapy may be more complex than for combining chemotherapy drugs.

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Tumor Immunotherapy with Combined Interleukins Injected Perilymphatically: Experimental and Clinicalnsplanted tumors grow and kill their host. Tumor cells can directly suppress host reactivity by secreting soluble mediators, and actively trigger specific or non-specific suppressor mechanisms that block both natural and adaptive host resistance..

GRILL

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Aspirin as a Biological Response Modifierstein’s laboratory looked at cyclooxygenase inhibitors, among other agents, to determine whether they might influence or inhibit thymic peptides. These studies demonstrated that acetyl salicylic acid (aspirin) could enhance immune responses and synergize with thymosins.

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