Titlebook: Clinical and Diagnostic Pathology of Graft-versus-Host Disease; Berno Heymer Book 2002 Springer-Verlag Berlin Heidelberg 2002 Alloimmune R

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Histopathological Manifestations of Acute GvHD,A presentation of the histopathology of acute GvHD comprises three aspects:

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Alan McKane,Michel Droz,Dietrich Wolfd by alloreactive donor T-lymphocytes recognizing minor or major histocompatibility antigens on target tissues of the host. GvHD primarily affects skin, liver, and gastrointestinal tract (GIT), but it can also involve other organs and tissues. The mortality of severe forms of acute GvHD can be very high, ranging from 50% to 90 % [ 139].

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Xue-Cheng Tai,Knut Mørken,Knut-Andreas Lied by routine histology. One asks whether some of these questions can be answered by immunohistology, proven to be a valuable diagnostic aid in other fields of pathology such as the typing of tumors or of glomerulonephritis [60].

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https://doi.org/10.1007/978-3-540-72823-8formalin-fixed paraffin-embedded tissues, as employed in routine pathology. This applies to the histomorphological and immunohistological investigations performed as well as to the published data cited. This should ensure that the findings reported are relevant to clinical and diagnostic pathology in man.

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Occurrence of GvHD,), severe combined immunodeficiency (SCID), leukemia, and many other diseases [69]. The spectrum of indications for allogeneic HSCTs has steadily increased in recent years. At present approximately 20,000 allogeneic or autologous HSCTs are performed worldwide every year [70]. Thus, it is not surpris

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Histopathological Manifestations of Chronic GvHD,ver, and GIT — it may involve many other organs and tissues [176, 255, 278, 284] . Chronic GvHD can manifest early or late, in a localized or generalized way, and, according to the type of onset, as progressive, quiescent, or de novo disease. In view of so many clinical variables it is not surprisin

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Immunohistological Features of GvHD,d by routine histology. One asks whether some of these questions can be answered by immunohistology, proven to be a valuable diagnostic aid in other fields of pathology such as the typing of tumors or of glomerulonephritis [60].