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Titlebook: Clinical Xenotransplantation; Pathways and Progres David K. C. Cooper,Guerard Byrne Book 2020 Springer Nature Switzerland AG 2020 surgery.t

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发表于 2025-3-21 17:25:46 | 显示全部楼层 |阅读模式
书目名称Clinical Xenotransplantation
副标题Pathways and Progres
编辑David K. C. Cooper,Guerard Byrne
视频video
概述First title of its kind that provides up-to-date information on the planning and preparation that goes toward clinical xenotransplantation.Features an authorship consisting of several leaders in the f
图书封面Titlebook: Clinical Xenotransplantation; Pathways and Progres David K. C. Cooper,Guerard Byrne Book 2020 Springer Nature Switzerland AG 2020 surgery.t
描述This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year.  Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made.  Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation.  .The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following thi
出版日期Book 2020
关键词surgery; transplant surgery; xenotransplantation; transplantation; hepatology; immunology; cellular biolog
版次1
doihttps://doi.org/10.1007/978-3-030-49127-7
isbn_softcover978-3-030-49129-1
isbn_ebook978-3-030-49127-7
copyrightSpringer Nature Switzerland AG 2020
The information of publication is updating

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发表于 2025-3-21 23:30:01 | 显示全部楼层
The Pathobiology of Pig-to-Primate Xeno.: A Historical Reviewthat bind to antigens expressed on the transplanted pig organ (the most important of which is galactose-α1,3-galactose [Gal]) and activate the complement cascade, which results in rapid destruction of the graft, a process known as hyperacute rejection. High levels of elicited anti-pig IgG may develo
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Is Sensitization to Pig Antigens Detrimental to Subsequent Allotransplantation?nograft. To answer this question, we have searched the literature. We primarily limited our review to the clinically relevant pig-to-nonhuman primate (NHP) model, and found five studies that explored this topic. No NHP that had received a pig graft developed antibodies to alloantigens, and in vitro
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Sensitization to Human Leukocyte Antigens and Xenotransplantationso the dominant polymorphic proteins targeted in allograft rejection. Sensitized patients with high levels of panel-reactive anti-HLA antibody (PRA) are at risk of early allograft injury, rejection, and reduced allograft survival, and they often experience prolonged waiting times prior to transplant
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Cardiac Xenotransplantation in Nonhuman Primates.g., in the neck or abdomen, of the recipient. This allowed observations to be made of rejection and of how this could be prevented by immunosuppressive therapy and/or immunomodulation procedures, e.g., anti-pig antibody adsorption. With the development of genetic engineering techniques, and the ava
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Addressing Regulatory Requirements for the Organ-Source Pig – A Pragmatic Approach to Facility Desigssigned regulatory responsibility for Xenotransplantation to the Center for Biologics Evaluation and Research. As a novel therapeutic, the Investigational New Drug Application will likely be subjected to review by a review committee assembled by the Office of Cellular, Tissue, and Gene Therapies. Th
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Management of Anti-HLA Antibodies and Acute Antibody-Mediated Rejectionplant. Patients who are sensitized to allo-human leukocyte antigen (HLA) have a primed humoral and cellular immune response, and many will have preformed donor-specific antibody (DSA). Desensitization protocols and treatment of antibody-mediated rejection in allotransplantation have made great progr
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