Titlebook: Clinical Trials of Antidepressants; How Changing the Mod Martin M. Katz Book 2016 The Author(s) 2016 depression.major depressive disorders.

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Aims and Basic Requirements of Clinical Trials: Conventional and Component-Specific Models,induced clinical actions, not only changes produced in the overall severity of the disorder. The goal of achieving secondary aims is to render the trial a sound, scientific experiment, not merely, an applied exercise designed to determine overall efficacy. The new models are designed specifically, t

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,Achieving the “Ideal” Clinical Trial: An Example of Applying the Merged Componential and Establisheided a good example of a “component-specific“ clinical trial. The results of that study are described demonstrating how the model works to achieve both the primary and secondary or profile of action results. The profile integrates the onset of clinical actions, the sequence, emphasizing the early or

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Comparing the Component-Specific Model Directly with the Established Diagnosis-Specific Trial,though both are equally strong in achieving the primary aim of evaluating overall efficacy, the established model has little to contribute to achieving the secondary aims. The chapter illustrates the importance of the secondary aims for advancing science in this area, generally. It highlights that l