Titlebook: Clinical Pharmacology in Psychiatry; Strategies in Psycho Lars F. Gram,Luc P. Balant,Svein G. Dahl Conference proceedings 1993 Springer-Ver

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https://doi.org/10.1007/978-3-642-48032-4ffect concept has usually been acknowledged, but the actual demonstration of dose-effect relationships in clinical drug research is often extremely difficult. In the early years after the introduction of imipramine and subsequently other tricyclic antidepressants (TCA), the dose-effect problems were

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E. Mertens,R. Fiedler,W. Sinzigsm in drug metabolism has been an area of particular interest. A genetic polymorphism is a monogenic or mendelian trait that exists in the population in at least two phenotypes (and presumably in at least two genotypes), the rarest of whom exists in at least 1%–2% (Vogel and Motulsky 1982). Thus, tw

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https://doi.org/10.1007/978-3-642-78010-3pharmacology; psychiatry; research

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E. Mertens,R. Fiedler,W. SinzigAntidepressant drugs have not been classified very systematically and no commonly accepted nomenclature has been developed. Classification has been based upon criteria as different as the time of development of the drugs, their chemical structure, their biochemical properties, and their behavioral effects.

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PET Examination of Central D2 Dopamine Receptor Occupancy in Relation to Extrapyramidal Syndromes its undergoing neuroleptic drug treatment. The dopamine hypothesis of antipsychotic drug action has been supported by consistent PET findings of a high D. dopamine receptor occupancy in patients treated with conventional clinical doses of chemically distinct classes of antipsychotic drugs (Farde et al. 1988; Smith et al. 1988; Baron et al. 1989).

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