Titlebook: Clinical Pharmacology in Psychiatry; Strategies in Psycho Lars F. Gram,Luc P. Balant,Svein G. Dahl Conference proceedings 1993 Springer-Ver

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Molecular Modeling of Neurotransmitter Receptors and Ligands, receptor (Sylte et al., to be published), and the 5-HT. receptor (Edvardsen et al. 1992), based on their amino acid sequence. The models were constructed by computer graphics and molecular modeling techniques, and used to examine the mechanisms of drug and neurotransmitter interactions with these receptors.

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Serotonin Receptor Subtypes,n or suspected subtypes - 5-HT., 5-HT., 5-HT. and 5-HT. - still remain to be cloned. At least one of these, the 5-HT. receptor(s), is a member of the multisubunit ligand-gated ion channel superfamily and likely to be unrelated in structure to the 7TM receptors known at this time.

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Methods to Facilitate Early Exploratory Testing of Novel Psychopharmacologic Agents in Humans, latter point, it is well known that even marketed psychotropic drugs have had very misleading dose recommendations because what is required for marketing is to establish safe doses which on average have a positive effect rather than doses which produce the maximum possible benefit.

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Psychopharmacology Serieshttp://image.papertrans.cn/c/image/228162.jpg

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Evaluation of Existing Fragility Curves,genes, two of which (β. and β.) are devoid of introns, have been isolated and sequenced. Structurally, the β-AR proteins display the typical hallmarks of all the other membrane R7G receptors coupled to GTP binding proteins, as represented in Fig. 1. They consist of: (a) a single polypeptide chain, 3