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Titlebook: Clinical Benefits of Leukodepleted Blood Products; Joseph Sweeney,Andrew Heaton Book 1995 Springer-Verlag Berlin Heidelberg 1995 attention

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发表于 2025-3-21 18:20:49 | 显示全部楼层 |阅读模式
书目名称Clinical Benefits of Leukodepleted Blood Products
编辑Joseph Sweeney,Andrew Heaton
视频video
丛书名称Medical Intelligence Unit
图书封面Titlebook: Clinical Benefits of Leukodepleted Blood Products;  Joseph Sweeney,Andrew Heaton Book 1995 Springer-Verlag Berlin Heidelberg 1995 attention
描述Joseph Sweeney, Andrew Heaton he presence of allogeneic leukocytes in blood products received little T attention until the mid-1950s when these "passenger" cells were im­ plicated in the etiology of febrile transfusion reactions, and early strate­ gies based on centrifugation were developed to effect their removal. In recent decades and, particularly in the past five years, there has been an accumulation of literature implicating leukocytes in a wide variety of undesirable reactions to blood transfusion. White cells are the least numerous of the cellular elements in blood and ratios of white cells to platelets and white cells to red cells are ap­ proximately 1:15 to 1:1000 respectively. This ratio is maintained in whole blood, but may be altered slightly in the process of component prepara­ tion. Any production or processing step which intentionally decreases this ratio will result in a product which can be described as white cell depleted. It has, however, become more common to define the outcome as a residual white cell content, rather than a decrease in cellular ratios, although the latter makes more sense on theoretical grounds, since deple­ tion of white cells needs to be put
出版日期Book 1995
关键词attention; blood; blood cell; cell; cells; cytokine; cytokines; heart; immunization; immunomodulation; lung; pr
版次1
doihttps://doi.org/10.1007/978-3-662-26538-3
isbn_softcover978-1-57059-122-8
isbn_ebook978-3-662-26538-3
copyrightSpringer-Verlag Berlin Heidelberg 1995
The information of publication is updating

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Enumeration of Low White Cells,popular method developed to prepare blood components depleted of WBC. Current filters are capable of removing more than 99.9% WBC (3 log. removal). Consequently, filtered products can contain as few as 1–10 WBC/µL (300,000–3,000,000 in a 300 mL unit), or less. At these levels routine WBC counting me
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Role of Contaminating White Blood Cells in the Storage Lesions of Red Cells and Platelets,whole blood donation. These white cells are predominantly granulocytes. Granulocytes may be metabolically active and release oxidant radicals. They certainly degenerate rapidly on storage, releasing proteolytic enzymes. Such substances may damage the red cell membrane, resulting in accelerated glyco
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Leukodepletion and Alloimmunization,ransfusion support. A number of recent studies have provided information about the role of the passenger leukocytes that remain in blood products and how these initiate antibody development by participating in the immunization process. Small numbers of leukocytes, 10.–10., may induce antibody develo
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Role of Donor Leukocytes and Leukodepletion in Transfusion-Associated Viral Infections,or leukocytes are directly involved in transmission of herpes viruses and retroviruses, agents which exist primarily as latent infections in lymphocytes of asymptomatic carriers. Controlled clinical studies have now established that filter-leukodepletion can prevent transmission of cytomegalovirus,
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Leukocyte Depletion and Transfusion-Induced Immunomodulation,of transfusion on cellular immune function. This includes down-regulation of effector cells, activation of latent viral infection, and the prolonged circulation of donor immunocompetent cells, as seen in graft-versus-host disease (GVHD)..In addition, there are now extensive data showing conclusively
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The Role of Leukocyte Depletion In Prevention of Transfusion-Related Acute Lung Injury,ry distress syndrome. The frequency of occurrence of TRALI is unknown, as it is likely that many cases go undiagnosed. TRALI is thought to be due to an interaction between granulocytes (most often of host, but possibly of donor origin) and anti-granulocyte antibodies (most often of donor but, someti
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