书目名称 | Immunological Aspects of Allergy and Allergic Diseases | 编辑 | E. Rajka,S. Korossy | 视频video | http://file.papertrans.cn/228/227787/227787.mp4 | 丛书名称 | Immunological Aspects of Allergy and Allergic Diseases | 图书封面 |  | 描述 | SPECIFICITY It is a basic assumption that, for reasons unknown, the constituents of the human body may become antigenic, and then the patient produces antibodies against them. Some autoantibodies are tissue specific (e.g. haemolytic anaemia, pernicious anaemia) whereas others are non-tissue specific (e.g. systemic lupus erythematosus). To prove ‘autoimmunity‘ in the strict sense is not an easy task. In any event, the outcome of antigenic stimulation-whether antibody formation or tolerance-seems to depend on the same factors for autoantigens as it does for any other antigen [146]. Rabbits rendered tolerant to bovine serum albumin respond to immunization with human serum albumin, and in doing so frequently produce antibodies that react with bovine serum albumin, which means the termination of tolerance. This is of special interest as a model of autoimmune disease since natural tolerance of body constituents might be terminated by immunization with a cross-reactive antigen from the environment (266]. It cannot be overemphasized how difficult it could be, at least in several in stances, to delineate specific from non-specific events in any immunological pro cess. Cyclic AMP may be on | 出版日期 | Book 1975 | 关键词 | antibody; antigen; autoimmune disease; autoimmunity; diseases; immunity; immunization; inflammation; lymphoc | 版次 | 1 | doi | https://doi.org/10.1007/978-1-4615-7237-4 | isbn_ebook | 978-1-4615-7237-4 | copyright | Springer-Verlag US 1975 |
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