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Titlebook: Clinical Applications of Immunotoxins; Arthur E. Frankel (Associate Professor of Medicine Book 1998 The Editor(s) (if applicable) and The

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书目名称Clinical Applications of Immunotoxins
编辑Arthur E. Frankel (Associate Professor of Medicine
视频videohttp://file.papertrans.cn/228/227752/227752.mp4
丛书名称Current Topics in Microbiology and Immunology
图书封面Titlebook: Clinical Applications of Immunotoxins; Arthur E. Frankel (Associate Professor of Medicine Book 1998 The Editor(s) (if applicable) and The
描述1 2 D. FITZGERALDI, I. PASTAN , and J. ROBERTUS Introduction . . . . . . . . . . . . . I 2 Toxin Structure-Function Properties 2 2. 1 Functions. . . . . . . . . . . . . . . . . . . . . . . . 2 2. 2 Binding. . . . . . . . . . . . . . . . . . . . . . . . . 3 3 Intracellular Processing - Cleavage and Reduction . . . . . . 4 3. 1 Cytosolic Activity . . . . . . . . . . . . . . . . 5 4 Immunotoxin Design and Testing. 6 5 Conclusion. . 8 References. . . . . 8 1 Introduction While various treatment approaches for cancer include reversal of the transformed phenotype, stimulation of immune responses, inhibition of metastatic spread and deprivation of key nutrients, the goal of immunotoxin treatment is the direct killing of malignant cells. Because they are enzymatic proteins that act catalytically to kill cells, bacterial and plant toxins are often employed as the cell-killing component of immunotoxins. Here we provide background information into the structure-func­ tion relationships of toxins and discuss how they can be combined with cell-binding antibodies or other ligands to generate immunotoxins. Bacterial and plant toxins (e. g. , diphtheria toxin, Pseudomonas exotoxin and ricin) are a
出版日期Book 1998
关键词Bakterium; bacteria; clinical trial; clinical trials; immunotherapy; leukemia; lymphoma; pharmacology; poiso
版次1
doihttps://doi.org/10.1007/978-3-642-72153-3
isbn_softcover978-3-642-72155-7
isbn_ebook978-3-642-72153-3Series ISSN 0070-217X Series E-ISSN 2196-9965
issn_series 0070-217X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
The information of publication is updating

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The Emerging Role of Ricin A-Chain Immunotoxins in Leukemia and Lymphoma,timately die of their disease. The major reason for this poor outcome is the persistence or selection of cells which are refractory to conventional treatment. These cells might be eradicated by new immunotherapeutic agents with different modes of action. In this regard, monoclonal antibodies (Moabs)
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Clinical Trials with Blocked Ricin Immunotoxins,unately, even with the development of innovative multi-drug treatment regimens and the increasing availability of both autologous bone marrow transplantation (ABMT) and peripheral blood stem cell transplantation (PBSCT), the clinician lacks the necessary tools to successfully combat the progression
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Diphtheria Toxin Fusion Proteins,ting of monoclonal antibodies chemically linked through a disulfide bond to a plant or bacterial toxin or radionuclide. Instability of the chemical conjugation of some of the earlier immunotoxins led to the concept of using protein engineering and recombinant DNA to assemble fusion genes combining t
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T. E. Cooke,J. Matatko,D. C. Staffordon of so many colleagues in this field in this book has been a reflection both of the kindness and friendliness of the individuals as well as their commitment to working together to develop a new class of human therapeutics.
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