Titlebook: Cirrhosis, Hepatic Encephalopathy, and Ammonium Toxicity; Santiago Grisolía,Vicente Felipo,María-Dolores Miñ Book 1990 The Editor(s) (if a

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Astrocytes in Hepatic Encephalopathyn integrated picture of all of the available facts and events regarding the pathogenesis of this condition has yet to emerge. Many studies to date have largely ignored certain fundamental cellular changes which occur in this condition. In this article, the involvement of astrocytes in HE will be rev

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Hepatic Encephalopathy, GABA-ergic Neurotransmission and Benzodiazepine Receptor Ligandstic failure (FHF) includes: (i) increased resistance to drugs which induce seizures by reducing GABAergic tone;(ii) abnormalities of visual evoked responses (VERs) which resemble those induced by drugs which augment GABAergic tone; (iii) increased sensitivity of CNS neurons to a GABA agonist; and (i

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Synaptic Plasma Membrane Composition and Fluidity in the Pathogenesis of Hepatic Encephalopathyhe neuromechanisms that might be operative in producing this disorder. While historically attention has focused on the role of actual or potential neurotoxins such as ammonia, short chain fatty acids (SCFA), and methylmercaptans, attention has more recently come to be focused on the role of endogeno

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Metabolic Effects of Carnitine and Carnitine Analogsion reactions and exposes the central nervous system (CNS) to amino acid imbalances and to multiple toxins including ammonia, mercaptans, short-chain fatty acids, and “middle” molecular weight molecules (2). Although all of these molecules contribute individually and perhaps synergistically to hepat

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Clinical Use of Carnitine Past, Present and Future in all tissues. However the last stage, hydroxylation of deoxycarnitine to carnitine, is restricted to liver, brain and, in humans, kidney (1). Therefore other tissues can export deoxycarnitine via the blood stream to these hydroxylating tissues, but for their own endogenous carnitine depend either

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Effect of L-Carnitine Upon Ammonia Tolerance Test in Cirrhotic Patientsmerical connection and star clock psychomotor tests has been evaluated..On comparing 40 LC patients given L-carnitine with 40 control cirrhotics given a placebo, no significant differences were observed in ammonium levels after performing the overload test in both groups..However, on studying the pa