Titlebook: Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring; An Introduction Peter B. Gahan Book 2015 Springer Science

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Dissection of Signaling Pathwaysunities for the analysis of cell-free nucleic acids. These genomic approaches have not only provided a more comprehensive portrait of the landscape of cell-free nucleic acids, but also enabled a number of non-invasive genome-wide diagnostic methods. In this chapter, we introduce the basic mechanism

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Posttranslational Modifications a precise diagnosis and therapy can be applied, the higher the probability of a successful treatment of the patients. Cell-free nucleic acids have promising clinical potential because they can critically be dysregulated during pathogenic processes. They are usually released during cellular stress o

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Dissection of Signaling Pathwayssource of fetal genetic material. Since fetal DNA coexists with a high background of maternal DNA in the maternal plasma, early studies in the field have been focused on the detection of paternally inherited sequences that are absent from the maternal genome. This approach has been applied to fetal

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https://doi.org/10.1007/978-1-59745-228-1and early detection of complications will help to reduce the adverse consequences. Current methods used for early detection of DM and its complications either have limitations or are expensive. Circulating miRNA and mRNA offer an exciting new approach to the diagnosis of diabetes and its complicatio

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Dissection of Signaling Pathways attracted much interest. According to our current knowledge it seems as if all tumor-associated alterations found in tumor cells are also found in the extracellular environment. The isolation of extracellular nucleic acids from tumor patients and its genetic characterization with very sensitive and

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Posttranslational Modificationsical signs and performing specific examinations such as imaging or blood analyses. This review focusses on the relevance of blood-based biomarker monitoring by circulating nucleic acids for diverse indications that is exemplified on patients who develop or suffer from cancer disease. These indicatio

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