Titlebook: Circadian Rhythms and Their Impact on Aging; S. Michal Jazwinski,Victoria P Belancio,Steven M H Book 2017 The Editor(s) (if applicable) an

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Circadian System and Aging in Rodent Models,tic (clock genes mutant/knockout mice) and environmental (light-dark regimens manipulation) circadian disturbance. In the end some interventions which may be used to improve circadian output are considered.

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Book 2017ism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book

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https://doi.org/10.1007/3-211-31908-5for orderly organizations of muscle mitochondria. Interestingly, . whole body knockout mice develop premature aging phenotypes, while AHA-1 over-expression increases lifespan in worms. Given that mitochondrial dysfunction appears to be a common feature associated with aging, obesity, and related met

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Gunther Maier,Franz Tödtling,Michaela Tripplch as cancer and diabetes and contributes to development of these pathologies. Both systems, the circadian clock and mTOR pathway, have been implicated in the control of aging in different organisms. Recently several groups reported on the existence of the crosstalk between the circadian clock and m