Titlebook: Ciclosporin in Autoimmune Diseases; 1st International Sy Rosemarie Schindler Conference proceedings 1985 Sandoz Ltd, Basle and Springer-Ver

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Clinical Effects and Renal Side Effects in Patients with Autoimmune Diseases Treated with Ciclosporiritis we have observed remission of vasculitic ulcers and skin lesions during treatment with CyA but only modest effects on inflammatory synovial reactions. In accordance with others [2, 3] we have achieved excellent clinical effects of CyA in patients with Behçet’s disease (n = 3) and patients with chronic uveitis (n = 3).

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Preface to CyA Proceedingssms of action it was self-evident that the new substance should be tested also in the wide field of autoimmune diseases. With this volume an attempt has been made to provide full information to the scientific community about the status of ciclosporin as a possible treatment in these indications.

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Pharmacokinetics and Interactions of Ciclosporinhibiting cell-cell communication [1]. In addition, augmentation of the inflammatory response is attenuated by blockade of macrophage migration inhibition factor (MIF) and macrophage arming factor (MAF), limiting the delayed-type hypersensitivity response and immunologically nonspecific tissue injury

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Ciclosporin-associated Nephropathynational conference on CyA held in Cambridge in 1981, it was concluded that CyA did not induce significant morphologic renal lesions in man [6], in contrast to animal experimental data [14]. Two years later, at the first international congress on CyA in Houston, several seemingly contradictory morph

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Ciclosporin in Autoimmune Diseases — Side Effects (with Emphasis on Renal Dysfunction) and Recommendatic clinical research programme of ciclosporin (CyA) treatment in various autoimmune diseases was undertaken in 1982. About 1000 patients have since been treated with CyA, and the side-effect profile is emerging.