Titlebook: Chronic Myeloid Leukemia; Methods and Protocol Shaoguang Li,Haojian Zhang Book 2016 Springer Science+Business Media New York 2016 Cancer st

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Histological and In Vivo Microscopic Analysis of the Bone Marrow Microenvironment in a Murine Modelcombination with various stainings that can help to understand the complex interaction between leukemic cells, their normal hematopoietic counterparts, and the bone marrow microenvironment. We conclude with describing how to image the bone marrow niche using in vivo microscopy.

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A Convenient Cell Culture Model for CML Acquired Resistance Through BCR-ABL Mutations, with therapeutically effective doses of TKIs, but the cells regrow quickly with development of resistance through BCR-ABL mutations. This model mimics the clinical process of acquisition of BCR-ABL mutations and will be an important tool to dissect molecular mechanisms of CML drug resistance and to explore strategies to overcome resistance.

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本能

Molecular Detection of BCR-ABL in Chronic Myeloid Leukemia,tic event in CML. Tyrosine kinase inhibitors (TKIs), such as imatinib, are synthesized small molecules that primarily target BCR-ABL tyrosine kinases and have become a first-line treatment for CML. Detection of BCR-ABL transcript level by real-time quantitative polymerase chain reaction (RQ-PCR) is

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繁荣中国

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