Titlebook: Chronic Lymphocytic Leukemia; Book 2005 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH,

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Gene Expression Patterns in Human and Mouse B Cell Development,lobulin genes. Recent studies have combined RNA amplification by in vitro transcription with high-density oligonucleotide array technology to generate gene expression profiles of ex vivo isolated B cell precursor stages from humans and mice. Cellular differentiation through five subsequent stages of

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What Do Somatic Hypermutation and Class Switch Recombination Teach Us About Chronic Lymphocytic Leu However, recent studies have shown that 50%–70% of CLL harbour somaticmutations of VH genes, as if they had matured in a lymphoid follicle. Interestingly, the presence or absence of somatic hypermutation (SHM) process is associated with the use of particular VH genes. Particular alleles of the V.1–

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Chronic Lymphocytic Leukaemia: A Review of the Immuno-architecture,blood, bone marrow or biopsied tissue. Immunohistochemical analysis on routine sections is less commonly performed; however, this approach allows the pathologist and the researcher to appreciate the immuno-architecture of the involved tissues and to gain insight into some of the events that influenc

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Clinical and Laboratory Parameters That Define Clinically Relevant B-CLL Subgroups,tients experience and by the marked variation in laboratory findings between patients. In this chapter, we will review the various clinical and laboratory parameters that divide B-CLL patients into “subgroups,” and correlate the parameters that define them.When feasible, we will also link clinical f

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Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements,ort provided by the different cellular components of the microenvironment where CLL cells accumulate. To this end we cultured purified CLL cells in vitro in the presence or absence of different accessory cells (stromal cells, autologous T lymphocytes) and/or soluble molecules (IL-4, sCD40L) and asse

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