Titlebook: Chronic Lymphocytic Leukemia; Book 2005 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH,

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Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements,s are involved in sustaining the survival of leukemic B cells, but indicate that their support is different in terms of time of onset and duration. T cells have a short-term support activity while stromal cells provide long-term support.

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Includes supplementary material:

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Chronic Lymphocytic Leukemia978-3-540-29933-2Series ISSN 0070-217X Series E-ISSN 2196-9965

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David Kitchin,Adrian Quark,Jayadev Misrawork of the available B cell differentiation scheme: First, the histology as well as the immunophenotype did not quite resemble that of any normal lymphocyte; second, in contrast to almost all other B cell tumor subtypes, the immunoglobulin variable region (IgV) genes of B-CLL cases could be either