Titlebook: Chromosomes Today; Volume 8 Proceedings M. D. Bennett,A. Gropp,U. Wolf Conference proceedings 1984 The Organising Committee of the VIII Int

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The synaptonemal complex in chromosome pairing and disjunctionaining one balanced genome. In eukaryotes pairing between homologous chromosomes or chromosome segments is mediated by the synaptonemal complex, which ensures that the homologous segments are held in register for a certain period of time — the pachytene stage (Westergaard and von Wettstein 1972). At

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X-inactivation and its role in male sterilitymale embryos both X chromosomes are active. After implantation, however, the paternally derived X is preferentially inactivated in extraembryonic tissues while the random inactivation of either paternal or maternal X occurs in primitive ectoderm which gives rise to the embryo proper later on (for re

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Age-related aneuploidy and its aetiology — testing some of the hypothesesnisms involved remains so inadequate. Probably no other aspect of human aneuploidy has attracted more attention over the years than the aetiology, and yet the cause of Down’s syndrome still eludes us and the factors underlying the maternal age effect remain obscure.

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Chromosomes and cancer: chromatin’s re-awakening may exist in the application and meaning of these terms. However, common usage during the years has led to an almost interchangeable application of these adjectives to similar, if not identical, phenomena.

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