Titlebook: Chromosomal Translocations and Oncogenic Transcription Factors; Frank J. Rauscher (Associate Professor Chair, Mole Book 1997 The Editor(s)

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Fusions Involving Paired Box and Fork Head Family Transcription Factors in the Pediatric Cancer Alvadolescents and young adults, often occurs in the extremities, and is associated with an unfavorable prognosis (. et al. 1992). This unfavorable prognosis is related to the propensity for early and wide dissemination, often involving bone marrow, and to the poor response to chemotherapy.

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0070-217X ation. The key players in these processes are sequence-specific DNA binding transcription factor proteins which coordinate programs of gene expression in the nucleus. The articles in this volume document the myriad of genetic and biochemical alterations sustained by human proto-oncogenic transcripti

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E2A-HLF Chimeric Transcription Factors in Pro-B Cell Acute Lymphoblastic Leukemia,mimicking the action of growth factors and their receptors, signal transducers, or nuclear regulatory proteins and transcription factors, which affect gene expression directly. Oncogenesis mediated by transcription factors is particularly important in the acute leukemias and sarcomas, malignancies i

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