Titlebook: Chromosomal Translocations and Genome Rearrangements in Cancer; Janet D. Rowley,Michelle M. Le Beau,Terence H. Rab Book 2015 Springer Inte

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Acute Promyelocytic Leukaemia: From a Specific Translocation to Cure by Targeted Therapies differentiation by a hormone, retinoic acid (RA), and the miraculous complete remissions that this drug yields in patients. This led to 25 years of extensive molecular explorations of the pathogenesis of this disease, starting with the identification of the retinoic acid receptor alpha (RARA) as th

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Fusion Oncogenes of Sarcomasction components and transcription factors. The oncogenes discussed here act as regulators of transcription. FET family and . oncoproteins bind DNA with target gene specificity causing specific tumour types with limited morphological variation. Tumours expressing . fusion proteins show larger morpho

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Molecular Genetics Methods in Discovery of Chromosome Structurees for high throughput or single cell analysis, for example, have been used to investigate the altered state of tumour genomes. Some of these methods have become the mainstay of clinical cancer diagnosis and patient management.

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Mechanisms of Recurrent Chromosomal Translocationsction forces, basic mechanistic factors, including DSB frequency and persistence, as well as aspects of three dimensional genome organization, can contribute to recurrent translocations in a cell population. This review discusses our current view of the contribution of such mechanistic factors to recurrent chromosomal translocations.

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Chronic Myeloid Leukaemiasuccessful therapeutic advance in CML. In this chapter, we review the implications of BCR-ABL1 signalling in CML, how this knowledge revolutionized CML treatment, and discuss approaches to further improving therapeutic response by the targeting of leukaemic stem cells.

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Chromosomal Translocations in B Cell Lymphomas the mechanisms and consequences of chromosomal translocations and other genetic lesions involved in the pathogenesis of the most common types of mature B cell lymphomas, including Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B Cell Lymphoma, and Burkitt Lymphoma.

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