Titlebook: Chromosomal Instability in Cancer Cells; B. Michael Ghadimi,Thomas Ried Book 2015 Springer International Publishing Switzerland 2015 Aneup

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Patterns of Chromosomal Aberrations in Solid Tumors,ations and copy number alterations, giving rise to aneuploid karyotypes. The increasing detection of these genetic changes allowed the description of specific tumor entities and the associated patterns of gene expression. In fact, tumor-specific landscapes of gross genomic copy number changes, inclu

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Yeast as Models of Mitotic Fidelity, haploid number. Aneuploidy is associated with human diseases including mental retardation, neurodegenerative diseases and cancer. In addition, aneuploidy is the major cause of spontaneous abortions and its occurrence increases with aging. Therefore, it is important to understand the molecular mecha

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The Diverse Effects of Complex Chromosome Rearrangements and Chromothripsis in Cancer Development,on types range from small substitutions to large structural genomic rearrangements, including complex reshuffling of the genome. Sets of mutations in individual cancer genomes may show specific signatures, which can be provoked by both exogenous and endogenous forces. One of the most remarkable muta