| 书目名称 | Chromosomal Instability in Cancer Cells |
| 编辑 | B. Michael Ghadimi,Thomas Ried |
| 视频video | http://file.papertrans.cn/227/226332/226332.mp4 |
| 概述 | Reviews up-to-date knowledge of chromosomal instability in cancer.Examines strategies to harness this information for the better treatment of cancer patients.Written by acknowledged experts in the fie |
| 丛书名称 | Recent Results in Cancer Research |
| 图书封面 |  |
| 描述 | .This issue of .Recent Results in Cancer Research. presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.. |
| 出版日期 | Book 2015 |
| 关键词 | Aneuploidy; Cancer; DNA Repair; Disease Outcome; Genomic Instability |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-20291-4 |
| isbn_softcover | 978-3-319-34962-6 |
| isbn_ebook | 978-3-319-20291-4Series ISSN 0080-0015 Series E-ISSN 2197-6767 |
| issn_series | 0080-0015 |
| copyright | Springer International Publishing Switzerland 2015 |
|Archiver|手机版|小黑屋|
派博传思国际
( 京公网安备110108008328)
GMT+8, 2025-8-18 20:14
发表于 2025-3-21 18:27:11
