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Titlebook: Childhood Leukemia: Present Problems and Future Prospects; Proceedings of the S Noboru Kobayashi,Tai Akera,Shuki Mizutani Conference procee

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Immunological Properties of Hematopoietic Malignancies in Childhoode histologically subtyped into lymphoblastic (LB,39%), Burkitt’s lymphoma (BL,31%), and large cell (LA,28%) types. BLs were all positive for pan B markers (immunoglobulins and CD 19/20/22), as well as the activated B-cell antigens, CD 10 and B5. However, BLs were phenotypically heterogenous with the
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Polymerase Chain Reaction Studies on Chronic Myelogenous Leukemias and Detection of Residual Ph1 Clo the polymerase chain reaction (PCR). In all samples the bcr-abl chimeric mRNA was detected. Seven cases showed bcr exon 2/abl exon 2 (b2-a) chimeric mRNA, 15 cases showed bcr exon 3/abl exon 2 (b3-a) chimeric mRNA, and 12 cases showed both of these mRNAs. None of the 34 samples with expression of b
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Lineage-Specific Classification of Childhood Leukemia and its Clinical Implicationsrthern blot analyses to define the lineage-specific classification of childhood leukemia. Phenotypically, they were divided into B lineage (62.6%), T lineage (9.8%), nonlymphoid (14.3%), and uncertain lineage (13.3%). Two of the B-lineage ALL and two of the T-lineage ALL studied did not show immunog
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Long-Term Survivors of Leukemia and Late Effects: A Report from the Registry of Long-Term Survivors ual patients are concerned, some patients, even nonrelapsed ones, have apparent abnormalities. However, as a population, significant abnormalities are not apparent. A large proportion of the patients in this study were treated before current treatment procedures came into widespread use, and this tr
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Therapy of Childhood Leukemia: Understanding Success and Failuregnancy. From the cautious use of single—agent chemotherapy in the 1950s, therapy has evolved to include the aggressive use of multiple agents. The results have been a progressive increase in remission frequency and remission duration. However, the most important outcome has been the increased cure r
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Results and Significance of Six Randomized Trials in Four Consecutive ALL-BFM Studieshe most important predicting factor for success or failure. The acute leukemias still need adequate management, no matter how the geno- or phenotype of the leukemic clone is characterized. Enforced by the antileukemic efficacy of improved therapy, some risk factors of the past have lost importance,
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