Titlebook: Chemotherapy; Frederick F. Becker Book 1977 Plenum Press, New York 1977 brain tumors.breast cancer.cancer.cell.chemotherapy.classification

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Alkylating Agents and the Nitrosoureashile interest in the distribution of alkylating agents has led to investigations of drug transport. Besides these and other contributions in the area of cancer chemotherapy, studies of alkylating agents have also increased our understanding of mutagenesis and chemical carcinogenesis.

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嘲笑

Björn Rasch,Wilhelm Hofmann,Ewald Naumannrious toxicities of the chemotherapeutic drugs so that these agents can be used as effectively as possible. Each drug has unique antitumor properties and, as would be expected, unique toxicities. Some toxicity is acute, some delayed, but it is always present. This chapter is a review of these toxicities.

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Quality of Service in Heterogeneous Networksesponsible for toxicity to malignant tissue, i.e., inhibition of dihydrofolate reductase. Significant injury to the liver, brain, and kidneys has also been seen as a consequence of antifolate therapy. These latter toxicities, which are not clearly related to reductase inhibition, will be considered later in this chapter.

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Book 1977 disease, and, therefore, its failures were felt all the more. Despite the serendipitous discoveries and inspired insights which tantalized us with striking remissions, or the rare tumors which proved to be fully susceptible to a given agent, in the main, there has been either total failure or a pai

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Factors That Influence the Therapeutic Responseacceleration phenomenon” in a retrospective analysis of children with acute leukemia treated with folate conjugates. This experience led him to a trial of folate antagonists, and in 1948, he reported dramatic responses in 10 of 16 children treated with the folate antagonist aminopterin (Farbet .., 1948).