Titlebook: Chemotherapy; Frederick F. Becker Book 1977 Plenum Press, New York 1977 brain tumors.breast cancer.cancer.cell.chemotherapy.classification

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Supportive Care in the Cancer Patientis the minimization or prevention of the common complications of cancer and its therapy. Although not unique to those with malignancy, the art and science of caring for their social, psychological, and somatic distress have become more highly developed than for perhaps any other single patient group

persistence

Metastasis

acquisition

Pyrimidine Antagonistsits unwelcome visitor. While this approach has been eminently successful in the case of bacterial, fungal, and, to some extent, parasitic infections, less impressive results, unfortunately, have been obtained with neoplastic disease. The reasons for this dichotomy become obvious when metabolic and s

antipsychotic

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Plant Alkaloidstion of garlic was recommended for skin disorders that may have included cancer. The same document described the use of the seeds of the autumn crocus, ., for joint pain, but a role for this plant or the less toxic . in treating cancer was not established until the time of Dioscorides in the 1st cen

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Antibiotics: Nucleic Acids As Targets in ChemotherapyAntibiotic inhibitors of protein biosynthesis are considerably less useful because they lack the required selectivity for neoplastic cells (see Goldberg ..,1975). All the agents discussed in this chapter alter DNA function (replication or transcription or both), but it has not been established in al

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Enzyme Therapyantagonists, or by modifying the structures of existing cellular components, e.g., alkylating and intercalating agents. Enzymes have been used in experimental therapeutic trials following these same mechanistic principles. Asparaginase, glutaminase, arginase, methioninase, .-tyrosinease, phenylalani

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Hydrazines and Triazenests, are relatively unstable, and provide biologically active groups on their decomposition and metabolism. The basic moieties of hydrazine, H.N-NH., and triazene, NH. N=NH, are substituted with aromatic and aliphatic groups on both ends of their nitrogen bridges; these substituents probably also pro

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