Titlebook: Chemogenomics; Methods and Protocol Daniel Merk,Apirat Chaikuad Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive

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Compilation of Custom Compound/Bioactivity Datasets from Public Repositories,positories to increase target coverage and data accuracy. Here, we present a workflow to generate custom datasets from public databases for mining chemogenomic compound candidates. The compiled set provides flags for differences in structural and bioactivity data and enables rapid extraction of potent and selective bioactive compounds.

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Plate-Based Screening for DUB Inhibitors,that control the removal of Ub, are emerging as therapeutic targets. Here, we describe a robust assay suitable for small-molecule inhibitor screening. This assay has the potential to drive the development of small-molecule compounds that can selectively target DUBs.

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https://doi.org/10.1007/978-3-319-66637-2s that drive novel biology. Additionally, the associated data deposited in the public domain have also been used to inform new inhibitor design. Further expansion of this set to complete kinome coverage will allow for a greater understanding of kinase biology and its role in disease.

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Abani K. Pradhan,Abhinav Mishra,Hao Pangheir calculated growth rate to determine a cytotoxic, cytostatic, or healthy outcome. All compounds affecting the growth rate can be further evaluated regarding their specific effects on cell health in a high-content live-cell multiplex assay, described in Chapter ..

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Jian Zhang,Zhiqiang Zhou,Tony T. Lee,Tong Yeel to identify small-molecule STEP inhibitors, we have developed a cellular target engagement assay that can identify compounds that interact with STEP.. We provide a comprehensive protocol to enable the use of this miniaturized assay, and we demonstrate its utility to benchmark the binding of newly discovered compounds.

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