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Titlebook: Chemistry and Biology of Pteridines and Folates; June E. Ayling,M. Gopal Nair,Charles M. Baugh Book 1993 The Editor(s) (if applicable) and

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Aspects of the MBFR NegotiationsThere is a paucity of detailed structural information on mammalian phenylalanine hydroxylase (PAH) mainly due to the fact that this enzyme has been difficult to crystallize. Equally there is a paucity of knowledge of the amino acids residues necessary for function. The main structural features described so far are shown in Table 1.
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A Re-Examination of the Metal Requirement of , Phenylalanine Hydroxylaseand tryptophan hydroxylase. All of the mammalian forms of these enzymes have a non-heme iron required for activity. . Though no direct experimental evidence ascribes a mechanistic role to the metal, it is thought that the metal ion is required to be in its lower oxidation state for activity..
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