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Titlebook: Chemistry and Biology of Pteridines and Folates; June E. Ayling,M. Gopal Nair,Charles M. Baugh Book 1993 The Editor(s) (if applicable) and

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The Mechanism of Cofactor Regeneration During Phenylalanine Hydroxylationverall process. This converts the oxidized form of cofactor, a quinoid dihydropterin., back to the starting tetrahydrobiopterin at the expense of NADH allowing cofactor to be used catalytically. The clinical symptoms of patients with a deficiency of DHPR have shown that cofactor regeneration is essential..
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Mechanistic Studies of Tyrosine Hydroxylasefunction of the central nervous system has resulted in a great deal of interest in the enzyme over the years, very little is known about the actual mechanism of catalysis. This report describes recent studies towards elucidating the mechanism of this important monooxygenase.
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Identification, Stereoconfiguration, Chromatographic and Fluorescence Properties of Natural Pterinss.. The present paper briefly reports an aspect of the method dealing with the fluorescence quantum yields of pterins and describes one application which answers the following questions : what is the stereoconfiguration of urinary monapterin ? Are there any differences in human urine from cancer and
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Expression of Wild Type and Mutant Forms of Human Phenylalanine Hydroxylase in ,. ,able forms of PAH in such . systems., and therefore only a few mutant forms have been further characterized so far. This led us to clone and express the normal and several mutated forms of human PAH cDNA into the pET-plasmid system of .. . (Novagen). Here we report the expression of both normal and
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Alleviation of Catecholamine Inhibition of Tyrosine Hydroxylase by Phosphorylation at Serine40d, and increases the Vmax value up to threefold. Much less work has been done with the physiological substrate tetrahydrobiopterin at the physiological pH of 7. Under these assay conditions with partially or fully purified enzyme, the effect on the KBH4 value is reported to be about threefold, while
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Glyceryl Ether Monooxygenase [EC 1.14.16.5]: Stoichiometry and Inhibition same. The second report was by Kötting, Unger and Eibl. who determined the stoichiometry of the reaction in a coupled reaction with DHPR and NADH, and showed that the amount of NADH oxidised after one minute was equivalent to the total amount of fatty aldehyde, alcohol and acid produced.. Since the
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0065-2598 are a reflection of the significant advances made since the Ninth International Symposium held in Zurich in 1989. Since the 7th International Symposium in St. 978-1-4613-6287-6978-1-4615-2960-6Series ISSN 0065-2598 Series E-ISSN 2214-8019
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